LL-37

LL-37 | Human Cathelicidin Antimicrobial Peptide | Research Reference Grade

LL-37 is the only known human cathelicidin. It is a 37 amino acid cationic host defence peptide, and the precursor protein hCAP-18 gives rise to its C-terminal region. PerformanceLabsUK supplies it strictly as a research reference material for in vitro laboratory investigation. Researchers must not use it for human or veterinary purposes.

This peptide represents a key component of innate immune defence. Consequently, it has attracted broad research interest, and is investigated in antimicrobial, immunomodulatory, wound-healing and cancer-biology research. For this reason, laboratories worldwide continue to investigate its multifunctional signalling roles.

LL-37 Research Interest Areas

• Researchers have studied this peptide extensively in innate immunity research. In particular, it shows broad-spectrum antimicrobial activity against gram-positive and gram-negative bacteria, fungi, and enveloped viruses.
• Scientists are examining it in wound healing biology for its stimulation of fibroblast and keratinocyte migration.
• Cancer researchers also show significant interest in this peptide. Specifically, it demonstrates selective cytotoxicity towards certain tumour cell lines in preclinical models.
• Additionally, investigators are studying it in autoimmune research. Notably, it plays complex dual roles in immune activation and suppression, depending on tissue context.

Primary Research Areas: Innate Immunity | Antimicrobial Research | Wound Healing | Cancer Biology | Immunomodulation

PerformanceLabsUK has every LL-37 batch tested by a third-party laboratory. A batch-specific Certificate of Analysis is available on request and will be published in our COA Library. Researchers investigating related host-defence peptides may also wish to review our Thymosin Alpha-1 research peptide. For structural and chemical reference data, see the independent PubChem listing. Overall, these resources support rigorous, reproducible laboratory research.

REGULATORY NOTICE
FOR LABORATORY RESEARCH USE ONLY, NOT INTENDED FOR HUMAN OR VETERINARY CONSUMPTION

Not a medicinal product, pharmaceutical, food supplement, or cosmetic. Not evaluated or approved by the MHRA, FDA, or any regulatory authority for use in humans or animals. Must not be used for diagnostic, therapeutic, or preventative purposes. Must be handled only by qualified professionals within a suitable research environment. By purchasing you confirm research-only use. Purchasers must be 18+. PerformanceLabsUK accepts no liability for misuse.

Further reading: LL-37 in Human Cathelicidin Research.