Research Education
PerformanceLabsUK supplies independently tested research reference materials for in vitro laboratory and scientific research use only, not for human or veterinary use.
Research Education
BPC-157 is a synthetic pentadecapeptide derived from a protein found in gastric juice, and TB-500 is a synthetic version of Thymosin Beta-4. Both are among the most published research peptides in the preclinical literature. This article records what published studies have examined, without any claim about human outcomes.
BPC-157, or Body Protection Compound-157, is a synthetic pentadecapeptide, a chain of 15 amino acids, derived from a naturally occurring protein found in gastric juice.
It was first identified and studied by researchers at the University of Zagreb, and has since become one of the more extensively published research peptides in the preclinical literature.
Most published BPC-157 work has been carried out in rodent models, examining gastrointestinal tissue at a cellular level, tendon and ligament tissue in animal injury models, angiogenesis, nitric oxide system modulation and neurological signalling pathways.
A 2018 review published in Current Neuropharmacology examined neurological research around BPC-157, noting its interaction with dopamine and serotonin systems in animal models. Research published in the Journal of Physiology and Pharmacology has explored its effects on gastrointestinal tissue in preclinical settings.
Human clinical trial data for BPC-157 remains very limited. The existing body of research is predominantly preclinical, and conclusions drawn from animal or in vitro studies cannot be extrapolated to human outcomes.
TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring peptide present in virtually all human and animal cells that plays a role in actin regulation.
Actin regulation is central to cell structure and movement, and Thymosin Beta-4 has been studied extensively in tissue repair research.
Published work on Thymosin Beta-4 and its synthetic analogue TB-500 has examined actin polymerisation and cellular migration in laboratory models, tissue repair mechanisms in animal studies, cardiac tissue in preclinical models, and inflammatory pathway modulation.
Research published in the Annals of the New York Academy of Sciences has explored the role of Thymosin Beta-4 in tissue repair mechanisms. Studies in the Journal of Molecular Medicine have examined its interaction with cellular signalling pathways in preclinical models. As with BPC-157, the human clinical trial literature is limited.
BPC-157 is a 15 amino acid synthetic peptide derived from a gastric protein, while TB-500 is a synthetic fragment analogue of Thymosin Beta-4. They differ in origin, sequence length and the molecular pathways published research has focused on.
| Attribute | BPC-157 | TB-500 |
|---|---|---|
| Structural class | Synthetic pentadecapeptide, 15 amino acids | Synthetic analogue of Thymosin Beta-4 |
| Origin of parent molecule | Protein found in gastric juice | Peptide present in most human and animal cells |
| Primary pathway in the literature | Angiogenesis and nitric oxide signalling | Actin regulation and cellular migration |
| Predominant model systems | Rodent models, in vitro tissue studies | Animal tissue repair models, in vitro cell studies |
| Human clinical trial data | Very limited | Limited |
| Supply status at PerformanceLabsUK | Research reference material, COA available | Research reference material, COA available |
Researchers should source only from suppliers that provide verifiable independent testing and batch specific COA documentation, and should work from the primary literature rather than secondary summaries.
At PerformanceLabsUK, both BPC-157 and TB-500 are supplied as independently tested research reference materials with batch specific COA documentation. Current documents are in the COA library.
Research use only means the material is supplied for in vitro laboratory and scientific research, and not for human or veterinary consumption, or for therapeutic, diagnostic, preventative or cosmetic use.
A Certificate of Analysis is a batch specific laboratory document that records the identity and purity testing results for one production lot of a material. Batch documents are available in the PerformanceLabsUK COA library.
Research reference materials can be supplied in the UK for laboratory research use. Supplying or promoting them for human use engages the Human Medicines Regulations 2012, which is why PerformanceLabsUK supplies strictly for research. More detail is in UK rules for research compounds.
Lyophilised peptides are generally held cold and protected from light, with the storage conditions for each material stated on its batch documentation.
Start with what are peptides for the underlying biochemistry, then UK rules for research compounds for the regulatory position.
Research content only. PerformanceLabsUK Ltd, company number SC883220, registered in Scotland.
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Peptide Science and Research Literacy. Written by us, free, and no jargon.
All products are supplied strictly for in vitro laboratory research use. Not for human or veterinary consumption.