MOTS-c

MOTS-c | Mitochondrial-Derived Peptide | Research Reference Grade

The mitochondrial genome encodes MOTS-c, a mitochondrial-derived peptide. PerformanceLabsUK supplies it strictly as a research reference material for in vitro laboratory investigation. Researchers must not use MOTS-c for human or veterinary purposes.

Areas of Research Interest

• Specifically, researchers study it for its potential role in AMPK pathway activation and cellular energy regulation.
• For example, scientists examine it in metabolic research models for its influence on insulin sensitivity and glucose uptake in skeletal muscle.
• In addition, longevity biology shows significant interest in this peptide, given the link between mitochondrial decline and biological ageing.
• Additionally, exercise physiology research explores its exercise-mimetic metabolic adaptations in preclinical models.
• In particular, investigators study its cross-compartmental nuclear gene expression signalling, a mechanism unique to mitochondrial-origin peptides.

Primary Research Areas: Metabolic Health | Insulin Sensitivity | Longevity | Exercise Physiology | Mitochondrial Biology

PerformanceLabsUK has every MOTS-c batch tested by a third-party laboratory. A batch-specific Certificate of Analysis is available on request and will be published in our COA Library. Researchers investigating related longevity and mitochondrial compounds may also wish to review our SS-31 research peptide. For structural and chemical reference data, see the independent PubChem listing.

REGULATORY NOTICE
FOR LABORATORY RESEARCH USE ONLY, NOT INTENDED FOR HUMAN OR VETERINARY CONSUMPTION

Not a medicinal product, pharmaceutical, food supplement, or cosmetic. Not evaluated or approved by the MHRA, FDA, or any regulatory
authority for use in humans or animals. Must not be used for diagnostic, therapeutic, or preventative purposes.
Must be handled only by qualified professionals within a suitable research environment. By purchasing you confirm research-only use.
Purchasers must be 18+. PerformanceLabsUK accepts no liability for misuse.

Further reading: MOTS-c and the Mitochondrial-Derived Peptides, and MOTS-c vs SS-31: Comparing Mitochondrial Peptide Research.

MOTS-c specifications

MOTS-c vs SS-31

Both compounds are studied in mitochondrial research but work in different ways. MOTS-c is encoded within mitochondrial DNA (the 12S rRNA region) and is studied as a signalling peptide. SS-31 is a synthetic tetrapeptide studied for its binding to cardiolipin on the inner mitochondrial membrane. Researchers comparing both can use the Mitochondrial Pair set, and the full range is in our mitochondrial research peptides category. For background, read MOTS-c and the Mitochondrial-Derived Peptides.

Storage and reconstitution

Store lyophilised MOTS-c at -20°C for long-term storage, or at 2–8°C for short-term storage, away from light and moisture. In the laboratory it is typically reconstituted with bacteriostatic water; our peptide reconstitution calculator works out the volume needed for a target concentration. Once reconstituted, keep refrigerated at 2–8°C and avoid repeated freeze-thaw cycles.

Batch documentation

Batch documentation is available on request, and published certificates of analysis are listed in our COA Library.

MOTS-c FAQ

Where can I buy MOTS-c in the UK?

PerformanceLabsUK supplies MOTS-c in the UK as a research reference material, dispatched by Royal Mail next-day. It is sold for in vitro laboratory research only and is not for human or veterinary use.

What is MOTS-c?

MOTS-c is a 16-amino acid peptide encoded by mitochondrial DNA, first described in 2015. It is one of a small group of mitochondrial-derived peptides studied in cellular energy and metabolic signalling research.

How should MOTS-c be stored?

Keep the lyophilised powder frozen at -20°C for long-term storage. After reconstitution, store at 2–8°C and avoid repeated freeze-thaw cycles.